Recent researches in triazole compounds as medicinal drugs

C -H. Zhou, Y Wang - Current medicinal chemistry, 2012 - benthamdirect.com
Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole
ring are readily able to bind with a variety of enzymes and receptors in biological system via …

Pharmacological significance of triazole scaffold

R Kharb, PC Sharma, MS Yar - Journal of enzyme inhibition and …, 2011 - Taylor & Francis
The triazole nucleus is one of the most important and well known heterocycles which is a
common and integral feature of a variety of natural products and medicinal agents. Triazole …

Recent advances bioactive 1, 2, 4-triazole-3-thiones

ŞG Küçükgüzel, P Çıkla-Süzgün - European journal of medicinal chemistry, 2015 - Elsevier
Triazoles are heterocyclic compounds which have a five-membered ring of two carbon
atoms and three nitrogen atoms. These structures have been interest in the development of …

Recent developments on triazole nucleus in anticonvulsant compounds: a review

MX Song, XQ Deng - Journal of enzyme inhibition and medicinal …, 2018 - Taylor & Francis
Epilepsy is one of the common diseases seriously threatening life and health of human.
More than 50 million people are suffering from this condition and anticonvulsant agents are …

Synthesis of novel 1, 3, 4-oxadiazole derivatives and their biological properties

A Husain, M Ajmal - Acta pharmaceutica, 2009 - hrcak.srce.hr
Sažetak A novel series of 2-[3-(4-bromophenyl) propan-3-one]-5-(substituted phenyl)-1, 3, 4-
oxadiazoles (4a-n) have been synthesized from 3-(4-bromobenzoyl) propionic acid (3) with …

Exploration of nonlinear optical properties of 4-methyl-4H-1,2,4-triazol-3-yl)thio)-N-phenylpropanamide based derivatives: experimental and DFT approach

M Irfan, HA Khan, S Bibi, G Wu, A Ali, SG Khan… - Scientific Reports, 2024 - nature.com
Triazoles, nitrogen-containing heterocycles, have gained attention for their applications in
medicinal chemistry, drug discovery, agrochemicals, and material sciences. In the current …

Chemistry and biology of indoles and indazoles: a mini-review

NA Shafakat Ali, B Ahmad Dar… - Mini reviews in …, 2013 - benthamdirect.com
The present review article is related with the method of preparation, importance and
medicinal application of indole and indazoles. The studies of heterocycles is an evergreen …

A comprehensive review of N-heterocycles as cytotoxic agents

D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

The importance of triazole scaffold in the development of anticonvulsant agents

A Ayati, S Emami, A Foroumadi - European journal of medicinal chemistry, 2016 - Elsevier
Epilepsy is one of the most important neurological disorders with high prevalence
worldwide. Many epileptic patients are not completely treated with available drugs and need …

Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1, 2, 4-triazoles

T Plech, JJ Luszczki, M Wujec, J Flieger… - European Journal of …, 2013 - Elsevier
Designed and synthesized 4-alkyl-1, 2, 4-triazole-3-thione derivatives showed significant
anticonvulsant activity, determined in the maximal electroshock-induced seizure (MES) test …