The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified
hundreds of risk variants potentially implicated in the disease. Further, novel statistical …

The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …

With the advent of post-genomic era, new technologies create extraordinary possibilities for
diagnostics and personalized therapy, transforming todays' medicine. Rooted in both …

Schizophrenia is a devastating mental disorder with a high societal burden, complex
pathophysiology, and diverse genetic and environmental risk factors. Its complexity …

Our hypothesis is that machine learning (ML) analysis of whole exome sequencing (WES)
data can be used to identify individuals at high risk for schizophrenia (SCZ). This study …

Dendrites of cortical pyramidal cells are densely populated by hyperpolarization-activated
cyclic nucleotide-gated (HCN) channels, aka I h channels. I h channels are targeted by …

Genome-wide association studies have implicated many ion channels in schizophrenia
pathophysiology. Although the functions of these channels are relatively well characterized …

Schizophrenia phenotypes are suggestive of impaired cortical plasticity in the disease, but
the mechanisms of these deficits are unknown. Genomic association studies have …

Despite an increasing body of evidence demonstrating subcellular alterations in
parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences …

The medial amygdala (MeA) is essential for processing innate social and non-social
behaviors, such as territorial aggression and mating, which display in a sex-specific manner …