Cellular senescence is a complicated process featured by irreversible cell cycle arrest and
senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent …

Brain natriuretic peptide (BNP) modulates several biological processes by activating the
natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases …

Animal models of allergic airways inflammation are useful tools in studying the pathogenesis
of asthma and potential therapeutic interventions. The different allergic airways inflammation …

Background and objective The pathology of asthma is characterized by airway inflammation
(granulocytic (GA) or paucigranulocytic (PGA)) and remodelling of airway structures …

Recent studies suggest that airway smooth muscle remodeling is an early event in the
course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled …

Abnormal growth of airway smooth muscle cells is one of the key features in asthmatic
airway remodeling, which is associated with asthma severity. The mechanisms underlying …

There is increasing evidence that vitamin A deficiency in utero correlates with abnormal
airway smooth muscle (SM) function in postnatal life. The bioactive vitamin A metabolite …

Exposure to diesel exhaust emissions (DEE) is strongly linked to innate immune injury and
lung injury, but the role of macrophage chemoattractant CXCL17 in the lung damage caused …

Vitamin D deficiency is associated with disease severity in asthma. We tested whether there
is a causal association between vitamin D deficiency, airway smooth muscle (ASM) mass …

BACKGROUND: Drugs targeting individual G protein–coupled receptors are used as
asthma therapies, but this strategy is limited because of G protein–coupled receptor signal …