Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
A proton-gated cation channel involved in acid-sensing
R Waldmann, G Champigny, F Bassilana, C Heurteaux… - Nature, 1997 - nature.com
Acid-sensing is associated with both nociception1 and taste transduction2. Stimulation of
sensory neurons by acid is of particular interest, because acidosis accompanies many …
sensory neurons by acid is of particular interest, because acidosis accompanies many …
Reducing the environmental sensitivity of yellow fluorescent protein: mechanism and applications
Yellow mutants of the green fluorescent protein (YFP) are crucial constituents of genetically
encoded indicators of signal transduction and fusions to monitor protein-protein interactions …
encoded indicators of signal transduction and fusions to monitor protein-protein interactions …
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure
S Kellenberger, L Schild - Physiological reviews, 2002 - journals.physiology.org
The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family
encodes sodium channels involved in various cell functions in metazoans. Subfamilies …
encodes sodium channels involved in various cell functions in metazoans. Subfamilies …
Regulation and modulation of pH in the brain
M Chesler - Physiological reviews, 2003 - journals.physiology.org
Chesler, Mitchell. Regulation and Modulation of pH in the Brain. Physiol Rev 83: 1183-1221,
2003; 10.1152/physrev. 00010.2003.—The regulation of pH is a vital homeostatic function …
2003; 10.1152/physrev. 00010.2003.—The regulation of pH is a vital homeostatic function …
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …
been the primary model organisms used for the study of various biological phenomena …
Dynamic and quantitative Ca2+ measurements using improved cameleons
A Miyawaki, O Griesbeck, R Heim… - Proceedings of the …, 1999 - National Acad Sciences
Cameleons are genetically-encoded fluorescent indicators for Ca2+ based on green
fluorescent protein variants and calmodulin (CaM). Because cameleons can be targeted …
fluorescent protein variants and calmodulin (CaM). Because cameleons can be targeted …
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease
Because regional blood flow increases in association with the increased metabolic demand
generated by localised increases in neural activity, functional imaging researchers often …
generated by localised increases in neural activity, functional imaging researchers often …
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
Many central neurons possess large acid-activated currents, yet their molecular identity is
unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H+ …
unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H+ …