The eye is a highly specialized organ that is subject to a huge range of pathology. Both local
and systemic disease may affect different anatomical regions of the eye. The least invasive …

In recent years, several cell-based screening technologies for the isolation of antibodies with
prescribed properties emerged. They rely on the multi-copy display of antibodies or antibody …

Bispecific antibodies enable unique therapeutic approaches but it remains a challenge to
produce them at the industrial scale, and the modifications introduced to achieve …

Adoptive immunotherapy with antigen-specific T cells has shown promise for the treatment
of malignancies. However, infused T cells are unable to redirect resident T cells, limiting …

The development of biopharmaceutical downstream processes relies on exhaustive
experimental studies. The root cause is the poorly understood relationship between the …

In order to overcome limitations of monoclonal antibodies, new protein-based scaffolds have
been designed and evaluated pre-clinically, and some of them are in clinical studies for the …

Antibody drugs have become an increasingly significant component of the therapeutic
landscape. Their success has been driven by some of their unique properties, in particular …

The investigational drug MP0250 is a multi-specific DARPin® molecule that simultaneously
binds and neutralizes VEGF and HGF with high specificity and affinity. Here we studied the …

Many biotherapeutics currently in development have complex mechanisms of action and
contain more than one domain, each with a specific role or function. Examples include …

Antibodies are essential components of the adaptive immune system that provide protection
from extracellular pathogens and aberrant cells in the host. Immunoglobulins G, which have …