Recent investigations in bacteria suggest that membraneless organelles play a crucial role
in the subcellular organization of bacterial cells. However, the biochemical functions and …

If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Structural maintenance of chromosomes (SMC) complexes play critical roles in chromosome
dynamics in virtually all organisms, but how they function remains poorly understood. In the …

During cell division, newly replicated DNA is actively segregated to the daughter cells. In
most bacteria, this process involves the DNA-binding protein ParB, which condenses the …

The spatial organization, correct expression, repair, and segregation of eukaryotic genomes
depend on cohesin, ring‐shaped protein complexes that are thought to function by …

Liquid-liquid phase-separated (LLPS) states are key to compartmentalizing components in
the absence of membranes; however, it is unclear whether LLPS condensates are actively …

Genome dynamics are intimately linked to the regulation of gene expression, the most
fundamental mechanism in biology, yet we still do not know whether the very process of …

Chromosomal phase separation is involved in a broad spectrum of chromosome
organization and functional processes. Nonetheless, the intricacy of this process has left its …

Proper chromosome segregation during cell division is essential in all domains of life. In the
majority of bacterial species, faithful chromosome segregation is mediated by the tripartite …

SMC condensin complexes play a central role in compacting and resolving replicated
chromosomes in virtually all organisms, yet how they accomplish this remains elusive. In …