There is increasing recognition of the importance of blood–brain barrier (BBB) disruption in
aging, dementia, stroke and multiple sclerosis in addition to more commonly-studied …

The blood–brain barrier (BBB) plays important roles in the maintenance of brain
homeostasis. Its main role includes three kinds of functions:(1) to protect the central nervous …

Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating
substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the …

Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

The neurovascular unit, which protects neuronal cells and supplies them with essential
molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The …

The blood–brain barrier (BBB) is located within a unique anatomic interface and has
functional ramifications to most of the brain and blood cells. In the past, the BBB was …

Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating
transport of most molecules to protect the brain microenvironment. Multiple structural and …

We have previously shown that Idazoxan (IDA), an imidazoline 2 receptor ligand, is
neuroprotective against spinal cord injury caused by experimental autoimmune …

Dynamic contrast-enhanced magnetic resonance imaging (DCE–MRI) is increasingly used
to estimate permeability in situations with subtle blood–brain barrier (BBB) leakage …

Purpose Dynamic contrast‐enhanced (DCE) MRI can be used to measure blood‐brain
barrier (BBB) leakage. In neurodegenerative disorders such as small vessel disease and …