Same substrate, many reactions: oxygen activation in flavoenzymes
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …
they perform a multitude of biological functions and adopt a diversity of chemical structures …
[HTML][HTML] Flavoprotein monooxygenases: versatile biocatalysts
Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …
Enzymatic dimerization in the biosynthetic pathway of microbial natural products
J Liu, A Liu, Y Hu - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to August 2020 The dramatic increase in the identification of dimeric natural
products generated by microorganisms and plants has played a significant role in drug …
products generated by microorganisms and plants has played a significant role in drug …
[HTML][HTML] The devil is in the details: The chemical basis and mechanistic versatility of flavoprotein monooxygenases
M Toplak, A Matthews, R Teufel - Archives of Biochemistry and Biophysics, 2021 - Elsevier
The ubiquitous flavoenzymes commonly catalyze redox chemistry such as the
monooxygenation of organic substrates and are both widely utilized in nature (eg, in primary …
monooxygenation of organic substrates and are both widely utilized in nature (eg, in primary …
Flavins as covalent catalysts: new mechanisms emerge
With approximately 1% of proteins being flavoproteins, flavins are at the heart of a plethora
of redox reactions in all areas of biology. Thanks to a series of fascinating recent …
of redox reactions in all areas of biology. Thanks to a series of fascinating recent …
Two-component FAD-dependent monooxygenases: current knowledge and biotechnological opportunities
T Heine, WJH Van Berkel, G Gassner, KH Van Pée… - Biology, 2018 - mdpi.com
Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …
Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis
The implementation of ortho-quinone methide (o-QM) intermediates in complex molecule
assembly represents a remarkably efficient strategy designed by Nature and utilized by …
assembly represents a remarkably efficient strategy designed by Nature and utilized by …
Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases
One of the hallmark reactions catalyzed by flavin-dependent enzymes is the incorporation of
an oxygen atom derived from dioxygen into organic substrates. For many decades, these …
an oxygen atom derived from dioxygen into organic substrates. For many decades, these …
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair
Halogenated pyrroles (halopyrroles) are common chemical moieties found in bioactive
bacterial natural products. The halopyrrole moieties of mono-and dihalopyrrole-containing …
bacterial natural products. The halopyrrole moieties of mono-and dihalopyrrole-containing …