Epigenetics of aging and aging-associated diseases
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Over the past decades, several hallmarks of aging have been defined, including epigenetic …
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
[HTML][HTML] The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks
Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …
major risk factor for cancer development. Due to advances in health care, hygiene control …
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-
associated decline in organ functions in mammals; however, the specific cell types and gene …
associated decline in organ functions in mammals; however, the specific cell types and gene …
Epigenetic mechanisms of aging and aging-associated diseases
A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …
From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
Reversing or slowing the aging process brings great promise to treat or prevent age‐related
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …
Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver
M Bozukova, C Nikopoulou… - Molecular Systems …, 2022 - embopress.org
Regulation of gene expression is linked to the organization of the genome. With age,
chromatin alterations occur on all levels of genome organization, accompanied by changes …
chromatin alterations occur on all levels of genome organization, accompanied by changes …
Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
C Cruz, M Della Rosa, C Krueger, Q Gao, D Horkai… - Elife, 2018 - elifesciences.org
Transcription of protein coding genes is accompanied by recruitment of COMPASS to
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
Astrocytes are highly specialised cells, responsible for CNS homeostasis and neuronal
activity. Lack of human in vitro systems able to recapitulate the functional changes affecting …
activity. Lack of human in vitro systems able to recapitulate the functional changes affecting …
Emerging role of HDACs in regeneration and ageing in the peripheral nervous system: repair Schwann cells as pivotal targets
The peripheral nervous system (PNS) has a remarkable regenerative capacity in
comparison to the central nervous system (CNS), a phenomenon that is impaired during …
comparison to the central nervous system (CNS), a phenomenon that is impaired during …