The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …
mechanical and electrical junctions. Although described in some detail by light microscopy …
Refining the molecular organization of the cardiac intercalated disc
SH Vermij, H Abriel, TAB van Veen - Cardiovascular research, 2017 - academic.oup.com
This review presents an extensively integrated model of the cardiac intercalated disc (ID), a
highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main …
highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main …
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
M Cerrone, J Montnach, X Lin, YT Zhao… - Nature …, 2017 - nature.com
Abstract Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …
The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation
Computational modeling indicates that cardiac conduction may involve ephaptic coupling–
intercellular communication involving electrochemical signaling across narrow extracellular …
intercellular communication involving electrochemical signaling across narrow extracellular …
Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms
The cardiac sodium channel NaV1. 5, encoded by the SCN5A gene, is responsible for the
fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel …
fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel …
Beta SARS-CoV-2 variant and BNT162b2 vaccine effectiveness in long-term care facilities in France
B Lefèvre, L Tondeur, Y Madec, R Grant… - The Lancet Healthy …, 2021 - thelancet.com
Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …
Cardiac Kir2.1 and NaV1.5 Channels Traffic Together to the Sarcolemma to Control Excitability
Rationale: In cardiomyocytes, NaV1. 5 and Kir2. 1 channels interact dynamically as part of
membrane bound macromolecular complexes. Objective: The objective of this study was to …
membrane bound macromolecular complexes. Objective: The objective of this study was to …
Murine electrophysiological models of cardiac arrhythmogenesis
CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
Voltage-gated sodium channel phosphorylation at Ser571 regulates late current, arrhythmia, and cardiac function in vivo
Background—Voltage-gated Na+ channels (Nav) are essential for myocyte membrane
excitability and cardiac function. Nav current (I Na) is a large-amplitude, short-duration spike …
excitability and cardiac function. Nav current (I Na) is a large-amplitude, short-duration spike …
Subcellular diversity of Nav1. 5 in cardiomyocytes: distinct functions, mechanisms and targets
In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …