This review presents an extensively integrated model of the cardiac intercalated disc (ID), a
highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Abstract Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in
cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening …

Computational modeling indicates that cardiac conduction may involve ephaptic coupling–
intercellular communication involving electrochemical signaling across narrow extracellular …

Rationale: In cardiomyocytes, NaV1. 5 and Kir2. 1 channels interact dynamically as part of
membrane bound macromolecular complexes. Objective: The objective of this study was to …

The cardiac sodium channel NaV1. 5, encoded by the SCN5A gene, is responsible for the
fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel …

Background—Voltage-gated Na+ channels (Nav) are essential for myocyte membrane
excitability and cardiac function. Nav current (I Na) is a large-amplitude, short-duration spike …

Ankyrins are membrane-associated proteins that together with their spectrin partners are
responsible for micron-scale organization of vertebrate plasma membranes, including those …

Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

The precise mechanisms by which oxidative stress (OS) causes atrial fibrillation (AF) are not
known. Since AF frequently originates in the posterior left atrium (PLA), we hypothesized that …