The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the
'apicoplast'. The discovery of the apicoplast ushered in an exciting new prospect for drug …

The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an
essential metabolic pathway in plants, apicomplexan parasites, and many species of …

Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to
its prokaryotic origin and essential function, the apicoplast is a key target for development of …

Isoprenoids are one of the largest groups of natural compounds and have a variety of
important functions in the primary metabolism of land plants and algae. In recent years, our …

Vitamin E is one of the 13 vitamins that are essential to animals that do not produce them. To
date, six natural organic compounds belonging to the chemical family of tocochromanols …

Antimicrobial drug resistance is an urgent problem in the control and treatment of many of
the world's most serious infections, including Plasmodium falciparum malaria, tuberculosis …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA)
metabolic pathway clinically modulated using statins. Curiously, two components of the MVA …

Apicomplexa are some of the most widespread and poorly controlled pathogens in the
world. The metabolism of lipids in these parasites, which include Plasmodium spp …

Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It
has provided researchers with a platform to combine powerful biochemical, statistical …