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The role of 3D genome organization in development and cell differentiation
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …
packaged inside the nucleus. This complex genome organization includes multiscale …
The roles of histone deacetylases and their inhibitors in cancer therapy
G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …
domains, for various cellular functions. However, their physical nature in living cells remains …
Dynamic organization of chromatin domains revealed by super-resolution live-cell imaging
T Nozaki, R Imai, M Tanbo, R Nagashima, S Tamura… - Molecular cell, 2017 - cell.com
The eukaryotic genome is organized within cells as chromatin. For proper information
output, higher-order chromatin structures can be regulated dynamically. How such structures …
output, higher-order chromatin structures can be regulated dynamically. How such structures …
[HTML][HTML] Microbiota-gut-brain axis: modulator of host metabolism and appetite
M Van de Wouw, H Schellekens, TG Dinan… - The Journal of nutrition, 2017 - Elsevier
The gut harbors an enormous diversity of microbes that are essential for the maintenance of
homeostasis in health and disease. A growing body of evidence supports the role of this …
homeostasis in health and disease. A growing body of evidence supports the role of this …
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
CJ Walker, C Crocini, D Ramirez, AR Killaars… - Nature biomedical …, 2021 - nature.com
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
SL McGee, M Hargreaves - Nature Reviews Endocrinology, 2020 - nature.com
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
Chromatin mechanics dictates subdiffusion and coarsening dynamics of embedded condensates
DSW Lee, NS Wingreen, CP Brangwynne - Biophysical Journal, 2021 - cell.com
DNA is organized into chromatin, a complex polymeric material which stores information and
controls gene expression. An emerging mechanism for biological organization, particularly …
controls gene expression. An emerging mechanism for biological organization, particularly …
[HTML][HTML] Beyond the sequence: cellular organization of genome function
T Misteli - Cell, 2007 - cell.com
Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …
structures, and their functional properties are strongly determined by their cellular …
The A-and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription
The nuclear lamins function in the regulation of replication, transcription, and epigenetic
modifications of chromatin. However, the mechanisms responsible for these lamin functions …
modifications of chromatin. However, the mechanisms responsible for these lamin functions …