Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …

Schizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations
worldwide with a grave disability and socioeconomic burden. Current antipsychotic …

Background With the increasing number of genomic sequencing studies, hundreds of genes
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …

Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic
susceptibility, and immune alterations. We aimed to identify differential transcriptional …

Psychosis occurs inside the brain, but may have external manifestations (peripheral
molecular biomarkers, behaviors) that can be objectively and quantitatively measured …

Abstract The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created
psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample …

Background Potential routes whereby systemic inflammation, oxidative stress and
mitochondrial dysfunction may drive the development of endothelial dysfunction and …

Abstract Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early
dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may …

Multiple lines of evidence implicate dysregulated microglia-mediated synaptic pruning in the
pathophysiology of schizophrenia. In vitro human cellular studies represent a promising …