Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …

Background The human virome consists of animal‐cell viruses causing transient infections,
bacteriophage (phage) predators of bacteria and archaea, endogenous retroviruses and …

Bacteriophages have important roles in the ecology of the human gut microbiome but are
under-represented in reference databases. To address this problem, we assembled the …

Ocean microbes drive biogeochemical cycling on a global scale. However, this cycling is
constrained by viruses that affect community composition, metabolic activity, and …

Metagenomics, or sequencing of the genetic material from a complete microbial community,
is a promising tool to discover novel microbes and viruses. Viral metagenomes typically …

Antibiotic resistance genes (ARGs) are pervasive in gut microbiota, but it remains unclear
how often ARGs are transferred, particularly to pathogens. Traditionally, ARG spread is …

In this review, we assess our current understanding of the role of bacteriophages infecting
the human gut bacterial community in health and disease. In general, bacteriophages …

Viruses that infect bacteria (phages) can influence bacterial community dynamics, bacterial
genome evolution and ecosystem biogeochemistry. These influences differ depending on …

Background Substantial efforts have been made to link the gut bacterial community to many
complex human diseases. Nevertheless, the gut phages are often neglected. Results In this …

Here, we outline our current understanding of the human gut virome, in particular the phage
component of this ecosystem, highlighting progress, and challenges in viral discovery in this …