Targeting cytokine and chemokine signaling pathways for cancer therapy
Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …
roles in both normal physiology and the pathology of diseases such as cancer. These …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
A novel protein encoded by exosomal CircATG4B induces oxaliplatin resistance in colorectal cancer by promoting autophagy
Z Pan, J Zheng, J Zhang, J Lin, J Lai, Z Lyu… - Advanced …, 2022 - Wiley Online Library
Oxaliplatin is commonly used in chemotherapeutic regimens for colorectal cancer (CRC)
after surgical resection. However, acquired chemoresistance seriously affects the curative …
after surgical resection. However, acquired chemoresistance seriously affects the curative …
Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma
W Liu, L Zheng, R Zhang, P Hou, J Wang, L Wu, J Li - Molecular Cancer, 2022 - Springer
Background Although the prognostic outcomes of liver cancer (LC) cases have improved
with the advancement in diagnostic technology and treatment methods, the transferability …
with the advancement in diagnostic technology and treatment methods, the transferability …
Circular RNA translation: novel protein isoforms and clinical significance
S Wen, J Qadir, BB Yang - Trends in molecular medicine, 2022 - cell.com
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …
determine its clinical significance. Cap-independent translation of circRNAs driven by an …
Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
J Wei, M Li, C Xue, S Chen, L Zheng, H Deng… - Journal of Experimental …, 2023 - Springer
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …
Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas
Y Wang, C Wu, Y Du, Z Li, M Li, P Hou, Z Shen, S Chu… - Molecular cancer, 2022 - Springer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …
Circular RNAs' cap-independent translation protein and its roles in carcinomas
L He, C Man, S ** in patients with gliomas
The lack of reliable predictive biomarkers to guide effective therapy is a major obstacle to the
advancement of therapy for high-grade gliomas, particularly glioblastoma (GBM), one of the …
advancement of therapy for high-grade gliomas, particularly glioblastoma (GBM), one of the …
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
L Yang, R Jia, T Ge, S Ge, A Zhuang, P Chai… - Signal transduction and …, 2022 - nature.com
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …