Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Abstract The Global Burden of Disease report of 2019 estimated 14 million infection‐related
deaths, making it the second leading cause of death after ischaemic heart disease. Bacterial …

The dearth of new medicines effective against antibiotic-resistant bacteria presents a
growing global public health concern. For more than five decades, the search for new …

The sulfonamides (sulfas) are the oldest class of antibacterial drugs and inhibit the bacterial
dihydropteroate synthase (DHPS, encoded by folP), through chemical mimicry of its co …

Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by
the classic membrane permeabilization model. Recently, the clinically vital but also highly …

The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

Constructing S-scheme heterojunction derived from metal-organic frameworks (MOFs) with
high photoredox ability and boosted charge separation efficiency is promising in …

Currently existing Fenton-like catalysts were limited in wastewater treatment owing to their
potential transition-metal poisoning, narrow applicable pH range and high dependence on …

Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with
protein biosynthesis. Macrolides represent one of the most successful classes of ribosome …

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structures of
biological macromolecular complexes. Picking single-protein particles from cryo-EM …