Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial
amount of research has been conducted to date to establish the anticancer potential of BBR …

Phosphatase of Regenerating Liver-3 (PRL3) was discovered in 1998 and was
subsequently found to be correlated with cancer progression and metastasis in 2001 …

Multiple myeloma (MM) is an incurable plasma cell malignancy for which novel treatment
options are required. Signal Transducer and Activator of Transcription 3 (STAT3) …

Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in
patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic …

The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …

Protein phosphatases are primarily responsible for dephosphorylation modification within
signal transduction pathways. Phosphatase of regenerating liver-3 (PRL-3) is a dual-specific …

PRL3, a unique oncotarget, is specifically overexpressed in 80.6% of cancers. In 2003, we
reported that PRL3 promotes cell migration, invasion, and metastasis. Herein, firstly, we …

Cancer cells often depend on microenvironment signals from molecules such as cytokines
for proliferation and metabolic adaptations. PRL‐3, a cytokine‐induced oncogenic …

Cancer cells are well-known for their capacity to adapt their metabolism to their increasing
energy demands which is necessary for tumor progression. This is no different for Multiple …

PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but
many studies have identified that PRL-3 is a marker of cancer progression and shown it to …