Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

Although oxaliplatin-based chemotherapy has been effective in the treatment of
hepatocellular carcinoma (HCC), primary or acquired resistance to oxaliplatin remains a …

Epstein–Barr virus (EBV) is a causative agent of infectious mononucleosis and several types
of cancer. Like other herpesviruses, it establishes an asymptomatic, life-long latent infection …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Abstract Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse
cellular processes, including tumorigenesis, and its overexpression is observed in cell lines …

The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-
dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is co-deleted with …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …