▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the
fundamental life processes they represent, but also because meiosis involves the formation …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Histone H3 lysine 9 methylation has been proposed to provide a major" switch" for the
functional organization of chromosomal subdomains. Here, we show that the murine Suv39h …

We targeted the locus encoding the cyclin-dependent kinase 2 (CDK2) by homologous
recombination in mouse embryonic stem (ES) cells. Embryonic fibroblasts lacking CDK2 …

During meiosis, the homologous chromosomes pair and recombine. An evolutionarily
conserved protein structure, the synaptonemal complex (SC), is located along the paired …

Meiosis is a special type of cell division that produces haploid gametes from diploid parental
cells. Chromosome number is reduced during meiosis because a single round of DNA …

In flowering plants, male reproductive development requires the formation of the stamen,
including the differentiation of anther tissues. Within the anther, male meiosis produces …

DMC1 is a meiosis-specific gene first discovered in yeast that encodes a protein with
homology to RecA and may be a component of recombination nodules. Yeast dmc1 mutants …

▪ Abstract The leptotene/zygotene transition of meiosis, as defined by classical cytological
studies, is the period when homologous chromosomes, already being discernible …

Prior to the pairing and recombination between homologous chromosomes during meiosis,
telomeres attach to the nuclear envelope and form a transient cluster. However, the protein …