Neutrophils in COVID-19

N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …

[HTML][HTML] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

J Schulte-Schrep**, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

Tissue-specific functions of invariant natural killer T cells

CM Crosby, M Kronenberg - Nature Reviews Immunology, 2018 - nature.com
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

The burgeoning family of unconventional T cells

DI Godfrey, AP Uldrich, J McCluskey, J Rossjohn… - Nature …, 2015 - nature.com
While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

Unconventional T cell targets for cancer immunotherapy

DI Godfrey, J Le Nours, DM Andrews, AP Uldrich… - Immunity, 2018 - cell.com
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …

Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

J Zhou, Y Nefedova, A Lei, D Gabrilovich - Seminars in immunology, 2018 - Elsevier
Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy

K Hadiloo, S Tahmasebi, A Esmaeilzadeh - Cancer Cell International, 2023 - Springer
Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Host recovery from respiratory viral infection

X Wei, H Narasimhan, B Zhu… - Annual Review of …, 2023 - annualreviews.org
Emerging and re-emerging respiratory viral infections pose a tremendous threat to human
society, as exemplified by the ongoing COVID-19 pandemic. Upon viral invasion of the …

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

PJ Brennan, M Brigl, MB Brenner - Nature Reviews Immunology, 2013 - nature.com
Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …