The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

The extracellular matrix (ECM) is a complex assembly of proteins that constitutes the scaffold
organizing cells, tissues, and organs. Over the past decade, mass-spectrometry-based …

Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Tumor-associated macrophages are a major constituent of malignant tumors and are known
to stimulate key steps in tumor progression. In our review in this journal in 2006, we …

Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterized by
immune structures called milky spots, but the cellular dynamics that direct this tropism are …

Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …

Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs)
play important roles in cancer progression. Here, we have characterized the ontogeny and …

Tumor-associated inflammation (TAI) is a feature of essentially all cancers and can confer
both tumor-promoting and-suppressive functions. Cancer-associated fibroblasts (CAF) …