A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge
Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …
challenged by a multitude of pathological conditions. While innovative approaches have …
[HTML][HTML] Biomaterial based modulation of macrophage polarization: a review and suggested design principles
Macrophages have long been known for their phagocytic capabilities and immune defence;
however, their role in healing is being increasingly recognized in recent years due to their …
however, their role in healing is being increasingly recognized in recent years due to their …
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
Engineering a pro-regenerative immune response following scaffold implantation is integral
to functional tissue regeneration. The immune response to implanted biomaterials is …
to functional tissue regeneration. The immune response to implanted biomaterials is …
[HTML][HTML] Effects of matrix stiffness on the morphology, adhesion, proliferation and osteogenic differentiation of mesenchymal stem cells
M Sun, G Chi, P Li, S Lv, J Xu, Z Xu, Y **a… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
BMMSCs have drawn great interest in tissue engineering and regenerative medicine
attributable to their multi-lineage differentiation capacity. Increasing evidence has shown …
attributable to their multi-lineage differentiation capacity. Increasing evidence has shown …
Physical cues of biomaterials guide stem cell differentiation fate
Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
Collagen scaffolds in cartilage tissue engineering and relevant approaches for future development
Background: Cartilage tissue engineering (CTE) aims to obtain a structure mimicking native
cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and …
cartilage tissue through the combination of relevant cells, three-dimensional scaffolds, and …
Scaffold mean pore size influences mesenchymal stem cell chondrogenic differentiation and matrix deposition
A Matsiko, JP Gleeson, FJ O'Brien - Tissue Engineering Part A, 2015 - liebertpub.com
Recent investigations into micro-architecture of scaffolds has revealed that mean pore sizes
are cell-type specific and influence cellular shape, differentiation, and extracellular matrix …
are cell-type specific and influence cellular shape, differentiation, and extracellular matrix …
Substrate stiffness controls osteoblastic and chondrocytic differentiation of mesenchymal stem cells without exogenous stimuli
Stem cell fate has been linked to the mechanical properties of their underlying substrate,
affecting mechanoreceptors and ultimately leading to downstream biological response …
affecting mechanoreceptors and ultimately leading to downstream biological response …
Cell-scaffold interactions in the bone tissue engineering triad.
Bone tissue engineering has emerged as one of the leading fields in tissue engineering and
regenerative medicine. The success of bone tissue engineering relies on understanding the …
regenerative medicine. The success of bone tissue engineering relies on understanding the …
Life in 3D is never flat: 3D models to optimise drug delivery
The development of safe, effective and patient-acceptable drug products is an expensive
and lengthy process and the risk of failure at different stages of the development life-cycle is …
and lengthy process and the risk of failure at different stages of the development life-cycle is …