Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

Alzheimer's disease (AD) is the most common cause of dementia and cognitive impairment;
yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative …

Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common
type of dementia in the elderly. The clinical symptoms of AD include a progressive loss of …

Alzheimer's disease (AD) is an irreversible, progressive neurological disorder characterized
by amyloid plaques, hyperphosphorylated tau protein (hyper p-tau), neuronal damage …

Curcumin is a natural product with multiple biological activities and numerous potential
therapeutic applications. However, its poor systemic bioavailability fails to explain the potent …

Alzheimer's disease (AD) is a polygenic multifactorial neurodegenerative disease that, after
decades of research and development, is still without a cure. There are some symptomatic …

The amyloid hypothesis has long been the central dogma in drug discovery for Alzheimer's
disease (AD), leading to many small-molecule and biological drug candidates. One major …

Develo** drugs for the central nervous system (CNS) requires fine chemical modifications,
as a strict balance between size and lipophilicity is necessary to improve the permeability …

Background The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in
Alzheimer's disease. However, BACE1 therapeutic inhibition may cause unwanted adverse …

Drug–drug interactions (DDIs) caused by the co‐administration of multiple drugs are major
safety concerns in the clinic. Several drugs have been withdrawn from the market due to …