Natural products: A lead for drug discovery and development

B Chopra, AK Dhingra - Phytotherapy Research, 2021 - Wiley Online Library
Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Nanoemulsion: Promising nanocarrier system for delivery of herbal bioactives

RK Harwansh, R Deshmukh, MA Rahman - Journal of Drug Delivery …, 2019 - Elsevier
The herbal medicines have been popularized throughout the globe since time immemorial.
Several plant based therapeutic leads have been produced through integrated approaches …

Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos

I Maji, S Mahajan, A Sriram, P Medtiya… - Journal of Controlled …, 2021 - Elsevier
A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

Lipid-based formulations for oral administration of poorly water-soluble drugs

H Mu, R Holm, A Müllertz - International journal of pharmaceutics, 2013 - Elsevier
Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly
water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed …

Application of surfactants in solid dispersion technology for improving solubility of poorly water soluble drugs

SP Chaudhari, RP Dugar - Journal of drug delivery science and technology, 2017 - Elsevier
Discovery of several poorly water soluble drugs in the past decade has led to the constant
need of develo** a novel dosage form which increases the solubility of these drug. They …

Lipid-based emulsion drug delivery systems—A comprehensive review

M Dhaval, P Vaghela, K Patel, K Sojitra, M Patel… - Drug delivery and …, 2022 - Springer
Lipid-based emulsion system—a subcategory of emulsion technology, has emerged as an
enticing option to improve the solubility of the steadily rising water-insoluble candidates …

Application of design of experiments in the development of self-microemulsifying drug delivery systems

CM Hsieh, TL Yang, AD Putri, CT Chen - Pharmaceuticals, 2023 - mdpi.com
Oral delivery has become the route of choice among all other types of drug administrations.
However, typical chronic disease drugs are often poorly water-soluble, have low dissolution …

Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS)

MA Rahman, A Hussain, MS Hussain… - Drug development …, 2013 - Taylor & Francis
The oral delivery of hydrophobic drug presents a major challenge because of the low
aqueous solubility of such compounds. Self-emulsifying/microemulsifying drug delivery …

Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs

P Tran, JS Park - Journal of Pharmaceutical Investigation, 2021 - Springer
Background The oral route is the most popular route for the clinical administration of drugs to
treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo …

Primaquine loaded solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and nanoemulsion (NE): effect of lipid matrix and surfactant on drug …

KW Wu, C Sweeney, N Dudhipala, P Lakhani… - AAPS …, 2021 - Springer
Abstract Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for
the eradication of hypnozoites from the liver and, therefore, recognized as the radical cure of …