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Targeting metaplasticity mechanisms to promote sustained antidepressant actions
The discovery that subanesthetic doses of (R, S)-ketamine (ketamine) and (S)-ketamine
(esketamine) rapidly induce antidepressant effects and promote sustained actions following …
(esketamine) rapidly induce antidepressant effects and promote sustained actions following …
[HTML][HTML] One path, two solutions: Network-based analysis identifies targetable pathways for the treatment of comorbid type II diabetes and neuropsychiatric disorders
Comorbid diseases complicate patient outcomes and escalate healthcare costs,
necessitating the need for a deeper mechanistic understanding. Neuropsychiatric disorders …
necessitating the need for a deeper mechanistic understanding. Neuropsychiatric disorders …
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies
B Chruścicka-Smaga, A Machaczka, B Szewczyk… - Pharmacological …, 2023 - Springer
The desire to find a gold-standard therapy for depression is still ongoing. Develo** one
universal and effective pharmacotherapy remains troublesome due to the high complexity …
universal and effective pharmacotherapy remains troublesome due to the high complexity …
(2R,6R)-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent mice
Opioid addiction is a pressing public health concern marked by frequent relapse during
periods of abstinence, perpetuated by negative affective states and anhedonia-driven …
periods of abstinence, perpetuated by negative affective states and anhedonia-driven …
[HTML][HTML] Ketamine and Hydroxynorketamine as Novel Pharmacotherapies for the Treatment of Opioid Use Disorders
Opioid use disorder (OUD) has reached epidemic proportions, with many countries facing
high levels of opioid use and related fatalities. Although currently prescribed medications for …
high levels of opioid use and related fatalities. Although currently prescribed medications for …
Network-Based Analysis Identifies Targetable Pathways in Comorbid Type II Diabetes and Neuropsychiatric Disorders
Comorbid diseases complicate patient outcomes and escalate healthcare costs,
necessitating a deeper mechanistic understanding. Neuropsychiatric disorders (NPDs) such …
necessitating a deeper mechanistic understanding. Neuropsychiatric disorders (NPDs) such …
Ketamine and hydroxynorketamine as novel pharmacotherapies for the treatment of Opioid-Use Disorders
O Anna, A Michael, M Apostolakis… - Biological … - biologicalpsychiatryjournal.com
Opioid use disorder (OUD) has reached epidemic proportions, with many countries facing
high opioid use and related fatalities. Although currently-prescribed medications for OUD …
high opioid use and related fatalities. Although currently-prescribed medications for OUD …
[SITAT][C] Role of mGlu receptors in psychiatric disorders-Recent Advances.
Role of mGlu receptors in psychiatric disorders -Recent Advances. - Abstract - Europe PMC Sign
in | Create an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact …
in | Create an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact …