In crossing a heath, suppose... I had found a watch upon the ground, and it should be
inquired how the watch happened to be in that place....[T] he inference, we think, is …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

One major challenge in nanomedicine is the selective delivery of nanoparticles to diseased
tissues. Nanoparticle delivery systems require targeting for specific delivery to pathogenic …

The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in
many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely …

Posters and lectures presented at the Seventh International Conference on Bioinorganic
Chemistry (ICBIC) in Lubeck, Germany, last year was divided into 16 sections, including …

The fact that natural β-sheet proteins are usually soluble but that fragments or designs of β
structure usually aggregate suggests that natural β proteins must somehow be designed to …

Metalloenzymes effect a variety of important chemical transformations, often involving small
molecule substrates or products such as molecular oxygen, hydrogen, nitrogen, and water …

The construction of complex protein folds relies on the precise conversion of a linear
polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link …

Metal ions are an important part of many natural proteins, providing structural, catalytic and
electron transfer functions. Reproducing these functions in a designed protein is the ultimate …

▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …