Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L.

R Alexova, S Alexandrova, S Dragomanova, R Kalfin… - Molecules, 2023 - mdpi.com
Pomegranate (Punica granatum L.) is a rich source of polyphenols, including ellagitannins
and ellagic acid. The plant is used in traditional medicine, and its purified components can …

Utilizing Andrographis paniculata leaves and roots by effective usage of the bioactive andrographolide and its nanodelivery: investigation of antikindling and …

R Baru Venkata, DSNBK Prasanth, PK Pasala… - Frontiers in …, 2023 - frontiersin.org
To valorise the bioactive constituents abundant in leaves and other parts of medicinal plants
with the objective to minimize the plant-based wastes, this study was undertaken. The main …

Identification of 1H-purine-2, 6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations

H Nada, A Elkamhawy, K Lee - PeerJ, 2022 - peerj.com
The rapid spread of the coronavirus since its first appearance in 2019 has taken the world by
surprise, challenging the global economy, and putting pressure on healthcare systems …

A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass

A Trezza, M Geminiani, G Cutrera, E Dreassi… - International Journal of …, 2024 - mdpi.com
Currently, many environmental and energy-related problems are threatening the future of
our planet. In October 2022, the Worldmeter recorded the world population as 7.9 billion …

Structure-based computational screening of 470 natural quercetin derivatives for identification of SARS-CoV-2 Mpro inhibitor

AK Umar, JH Zothantluanga, JA Luckanagul… - PeerJ, 2023 - peerj.com
Abstract Coronavirus disease 2019 (COVID-19) is a global pandemic infecting the
respiratory system through a notorious virus known as the severe acute respiratory …

Analgesic and anti-inflammatory potential of indole derivatives

M Rudrapal, I Celik, S Chinnam, UA Çevik… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Some indole analogues show a good analgesic activity but on the other hand, it has some
serious side effects like gastric ulcer. Therefore, there is still a need to develop derivatives of …

Multi-target molecular dynamic simulations reveal glutathione-S-transferase as the most favorable drug target of knipholone in Plasmodium falciparum

M Sarma, M Abdalla, JH Zothantluanga… - Journal of …, 2023 - Taylor & Francis
Knipholone is an antiplasmodial phytocompound obtained from the roots of Kniphofia
foliosa. Despite several available studies, the molecular drug targets of knipholone in P …

Resveratrol and Its Natural Analogues Inhibit RNA Dependant RNA Polymerase (RdRp) of Rhizopus oryzae in Mucormycosis through Computational Investigations

I Celik, M Rudrapal, PK Yadalam… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Mucormycosis (or black fungus infection) is a life-threatening, but rare fungal infection with
predominant occurrence in immunosuppressed patients following the SARS-CoV-2 …

Pea eggplant (Solanum torvum Swartz) is a source of plant food polyphenols with SARS-CoV inhibiting potential

N Govender, NS Zulkifli, NFB Hisham, NS Ab Ghani… - PeerJ, 2022 - peerj.com
Background Pea eggplant (Solanum torvum Swartz) commonly known as turkey berry or
'terung pipit'in Malay is a vegetable plant widely consumed by the local community in …

The flavonoid Sudachitin regulates glucose metabolism via PDE inhibition

R Hatanaka, A Taguchi, Y Nagao, K Yorimoto… - Heliyon, 2024 - cell.com
Sudachitin, a member of the flavonoid family, reportedly improves glucose metabolism after
long-term administration, but details of the underlying mechanisms are unknown. We found …