Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal,
and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common …

Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …

Central nervous system (CNS) diseases are among the major health problems. However,
blood-brain barrier (BBB) makes traditional oral and intravenous delivery of CNS drugs …

Erythromycin (EM) is a macrolide antibiotic that is frequently used to treat skin bacterial
infections. It has a short half-life (1–1.5 h), instability in stomach pH, and a low oral …

Brucine (BRU) as a natural alkaloid has antitumor, anti-inflammatory and anti-proliferation
activity However; its clinical application is limited due to its low water solubility. The aim of …

Despite their conventional and widespread use, oral and intravenous routes of drug
administration face several limitations. In particular, orally administered drugs undergo …

Glaucoma, the multifactorial disease of the eye, is characterized by many biological risk
factors as well as genetic factors which lead to degeneration of optic nerves. The major …

Background Polysaccharides acceded by the Food and Drug Administration are among the
most exploitable polymers for fabricating nasally applied vehicles containing therapeutically …

Current advancements in the research investigations focused at using natural products to
generate novel dosage forms with a potential therapeutic impact. Silymarin is a natural …