Drosophila melanogaster as a model organism for Alzheimer's disease
K Prüßing, A Voigt, JB Schulz - Molecular neurodegeneration, 2013 - Springer
Drosophila melanogaster provides an important resource for in vivo modifier screens of
neurodegenerative diseases. To study the underlying pathogenesis of Alzheimer's disease …
neurodegenerative diseases. To study the underlying pathogenesis of Alzheimer's disease …
Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated
ailments characterized by interrupting cellular proteostasic machinery and the misfolding of …
ailments characterized by interrupting cellular proteostasic machinery and the misfolding of …
Modeling Alzheimer's Disease in Caenorhabditis elegans
J Alvarez, P Alvarez-Illera, J Santo-Domingo… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …
we know the importance of the accumulation of protein aggregates such as β-amyloid …
Connecting the dots between tau dysfunction and neurodegeneration
Tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are
histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated …
histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated …
Drosophila as a Model to Study the Relationship Between Sleep, Plasticity, and Memory
S Dissel - Frontiers in physiology, 2020 - frontiersin.org
Humans spend nearly a third of their life slee**, yet, despite decades of research the
function of sleep still remains a mystery. Sleep has been linked with various biological …
function of sleep still remains a mystery. Sleep has been linked with various biological …
Discovery of a new donepezil-like acetylcholinesterase inhibitor for targeting Alzheimer's disease: computational studies with biological validation
BA Akhoon, S Choudhary, H Tiwari… - Journal of Chemical …, 2020 - ACS Publications
Alzheimer's disorder is one of the most common worldwide health problems, and its
prevalence continues to increase, thereby straining the healthcare budgets of both …
prevalence continues to increase, thereby straining the healthcare budgets of both …
Synaptic abnormalities in a Drosophila model of Alzheimer's disease
SD Mhatre, V Satyasi, M Killen… - Disease models & …, 2014 - journals.biologists.com
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
memory loss and decreased synaptic function. Advances in transgenic animal models of AD …
memory loss and decreased synaptic function. Advances in transgenic animal models of AD …
Identification of a novel Wnt antagonist based therapeutic and diagnostic target for Alzheimer's disease using a stem cell-derived model
Currently, all the existing treatments for Alzheimer's disease (AD) fail to stall progression due
to longer duration of time between onset of the symptoms and diagnosis of the disease …
to longer duration of time between onset of the symptoms and diagnosis of the disease …
[HTML][HTML] Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's
disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein …
disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein …
Dopamine, sleep, and neuronal excitability modulate amyloid-β–mediated forgetting in Drosophila
JC Kaldun, SR Lone, AM Humbert Camps… - PLoS …, 2021 - journals.plos.org
Alzheimer disease (AD) is one of the main causes of age-related dementia and
neurodegeneration. However, the onset of the disease and the mechanisms causing …
neurodegeneration. However, the onset of the disease and the mechanisms causing …