[HTML][HTML] Proteomic Analysis and Biochemical Characterization of the Nematocyst Extract of the Hydrozoan Velella velella

E Tassara, I Mikšík, P Pompach, GL Mariottini, L **ao… - Marine Drugs, 2024 - mdpi.com
The venom contained within cnidarian nematocysts has a complex composition and holds
significant potential for biotechnological applications. In this context, one of the most …

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo

TB Smallwood, S Navarro, B Cristofori-Armstrong… - Journal of Biological …, 2021 - jbc.org
The prevalence of autoimmune diseases is on the rise globally. Currently, autoimmunity
presents in over 100 different forms and affects around 9% of the world's population. Current …

Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

K Steffen, Q Laborde, S Gunasekera… - Journal of Natural …, 2021 - ACS Publications
Natural product discovery by isolation and structure elucidation is a laborious task often
requiring ample quantities of biological starting material and frequently resulting in the …

A chameleonic macrocyclic peptide with drug delivery applications

CD Payne, B Franke, MF Fisher, F Hajiaghaalipour… - Chemical …, 2021 - pubs.rsc.org
Head-to-tail cyclized peptides are intriguing natural products with unusual properties. The
PawS-Derived Peptides (PDPs) are ribosomally synthesized as part of precursors for seed …

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3. 3 and CaV3. 2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical …

D Wang, V Herzig, Z Dekan, KJ Rosengren… - International Journal of …, 2024 - mdpi.com
Venom peptides have evolved to target a wide range of membrane proteins through diverse
mechanisms of action and structures, providing promising therapeutic leads for diseases …

Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides

CD Payne, G Vadlamani, F Hajiaghaalipour… - RSC chemical …, 2021 - pubs.rsc.org
Head-to-tail cyclic and disulfide-rich peptides are natural products with applications in drug
design. Among these are the PawS-Derived Peptides (PDPs) produced in seeds of the daisy …

Development of Synthetic Human and Mouse C5a: Application to Binding and Functional Assays In Vitro and In Vivo

DM Gorman, XX Li, CD Payne, CS Cui… - ACS Pharmacology & …, 2021 - ACS Publications
The complement activation peptide C5a is a key mediator of inflammation that is associated
with numerous immune disorders. C5a binds and activates two seven-transmembrane …