Tight junctions are complex supramolecular entities composed of integral membrane
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

Summary The type III-E CRISPR-Cas effector Cas7-11, with dual RNase activities for
precursor CRISPR RNA (pre-crRNA) processing and crRNA-guided target RNA cleavage, is …

In eukaryotic cells, a multitude of RNA-binding proteins play key roles in the
posttranscriptional regulation of gene expression. Characterization of these proteins has led …

Mutations in the heterochronic gene lin-28 of C. elegans cause precocious development
where diverse events specific to the second larval stage are skipped. lin-28 encodes a …

Vitrification is an alternative approach to cryopreservation that enables hydrated living cells
to be cooled to cryogenic temperatures in the absence of ice. Vitrification simplifies and …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

We present a systematic analysis of sequence motifs found in metazoan protein factors
involved in constitutive pre-mRNA splicing and in alternative splicing regulation. Using …

Modern enzyme development relies to an increasing extent on strategies based on diversity
generation followed by screening for variants with optimised properties. In principle, these …

The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-
positive proteins and their degradation by autophagy, but the molecular mechanism of p62 …