ORF45, a multifunctional immediate early and tegument protein of KSHV

Q Liang, F Zhu - Journal of Medical Virology, 2023 - Wiley Online Library
Kaposi sarcoma‐associated herpesvirus (KSHV) is the etiological agent of several human
diseases, including Kaposi sarcoma, primary effusion lymphoma, and a subset of …

[HTML][HTML] The ORF45 protein of kaposi's sarcoma-associated herpesvirus and its critical role in the viral life cycle

N Atyeo, B Papp - Viruses, 2022 - mdpi.com
Kaposi's sarcoma-associated herpesvirus (KSHV) protein ORF45 is a virion-associated
tegument protein that is unique to the gammaherpesvirus family. Generation of KSHV …

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation

NR Sharma, V Majerciak, MJ Kruhlak… - PLoS …, 2017 - journals.plos.org
TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are
often associated with the cellular antiviral response. In this report, we provide evidence that …

Epstein-Barr virus BKRF4 gene product is required for efficient progeny production

HMAA Masud, T Watanabe, M Yoshida, Y Sato… - Journal of …, 2017 - journals.asm.org
ABSTRACT Epstein-Barr virus (EBV), a member of human gammaherpesvirus, infects
mainly B cells. EBV has two alternative life cycles, latent and lytic, and is reactivated …

Better late than never: A unique strategy for late gene transcription in the beta-and gammaherpesviruses

SE Dremel, AL Didychuk - Seminars in cell & developmental biology, 2023 - Elsevier
During lytic replication, herpesviruses express their genes in a temporal cascade
culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta-and …

A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host

A Alexa, P Sok, F Gross, K Albert, E Kobori… - Nature …, 2022 - nature.com
The Kaposi's sarcoma associated herpesvirus protein ORF45 binds the extracellular signal-
regulated kinase (ERK) and the p90 Ribosomal S6 kinase (RSK). ORF45 was shown to be a …

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

AT Olson, Y Kang, AM Ladha, S Zhu, CB Lim… - PLoS …, 2023 - journals.plos.org
Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human diseases
including Kaposi's sarcoma (KS), a leading cause of cancer in Africa and in patients with …

KSHV viral protein kinase interacts with USP9X to modulate the viral lifecycle

DL Chappell, PK Sandhu, JP Wong, AP Bhatt… - Journal of …, 2023 - journals.asm.org
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi sarcoma
(KS), the plasmablastic form of multicentric Castleman's disease, and primary effusion …

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

B Bogdanow, M Schmidt, H Weisbach, I Gruska… - Nature …, 2020 - nature.com
Herpesviruses encode conserved protein kinases (CHPKs) to stimulate phosphorylation-
sensitive processes during infection. How CHPKs bind to cellular factors and how this …

Mechanism of herpesvirus protein kinase UL13 in immune escape and viral replication

L Zhou, A Cheng, M Wang, Y Wu, Q Yang… - Frontiers in …, 2022 - frontiersin.org
Upon infection, the herpes viruses create a cellular environment suitable for survival, but
innate immunity plays a vital role in cellular resistance to viral infection. The UL13 protein of …