Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying
mechanisms are poorly understood. We describe an mTOR-driven mouse model that …

Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their
quantitative determination may be informative about pathogenic conditions. We searched for …

Peroxisomes and mitochondria are ubiquitous, highly dynamic organelles with an oxidative
type of metabolism in eukaryotic cells. Over the years, substantial evidence has been …

Peroxisomes are essential organelles for the specialized oxidation of a wide variety of fatty
acids, but they are also able to degrade fatty acids that are typically handled by …

Medium-and long-chain triacylglycerol (MLCT) is a structured lipid with both medium-and
long-chain fatty acids in one triacylglycerol molecule. Compared with long-chain …

Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty
acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source …

Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but
alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and …

Abstract Medium-chain triglycerides (MCT), containing C8–C12 fatty acids, are used to treat
several pediatric disorders and are widely consumed as a nutritional supplement. Here, we …