Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Recent progress in the science of complex coacervation

CE Sing, SL Perry - Soft Matter, 2020 - pubs.rsc.org
Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

Driving force and pathway in polyelectrolyte complex coacervation

S Chen, ZG Wang - Proceedings of the National Academy of Sciences, 2022 - pnas.org
There is notable discrepancy between experiments and coarse-grained model studies
regarding the thermodynamic driving force in polyelectrolyte complex coacervation …

Modeling and simulations of polymers: a roadmap

TE Gartner III, A Jayaraman - Macromolecules, 2019 - ACS Publications
Molecular modeling and simulations are invaluable tools for the polymer science and
engineering community. These computational approaches enable predictions and provide …

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

50th Anniversary Perspective: A Perspective on Polyelectrolyte Solutions

M Muthukumar - Macromolecules, 2017 - ACS Publications
From the beginning of life with the information-containing polymers until the present era of a
plethora of water-based materials in health care industry and biotechnology, polyelectrolytes …

Driving forces for oppositely charged polyion association in aqueous solutions: enthalpic, entropic, but not electrostatic

J Fu, JB Schlenoff - Journal of the American Chemical Society, 2016 - ACS Publications
Driving forces for association between oppositely charged biological or synthetic polymers
in aqueous solution have long been identified as electrostatic in origin. This attraction is …

Development of the modern theory of polymeric complex coacervation

CE Sing - Advances in colloid and interface science, 2017 - Elsevier
Oppositely charged polymers can undergo the process of complex coacervation, which
refers to a liquid–liquid phase separation driven by electrostatic attraction. These materials …

Recent advances in amino acid N-carboxyanhydrides and synthetic polypeptides: chemistry, self-assembly and biological applications

H Lu, J Wang, Z Song, L Yin, Y Zhang… - Chemical …, 2014 - pubs.rsc.org
Polypeptides are fascinating materials with unique properties for various biological
materials. We highlight here recent advances in amino acid N-carboxyanhydrides (NCAs) …

Beyond lipids: exploring advances in polymeric gene delivery in the lipid nanoparticles era

CM Jogdeo, K Siddhanta, A Das, L Ding… - Advanced …, 2024 - Wiley Online Library
The recent success of gene therapy during the COVID‐19 pandemic has underscored the
importance of effective and safe delivery systems. Complementing lipid‐based delivery …