Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …

Liver injury is a common pathological process, which can result in fatty liver, cirrhosis,
fibrosis and even cancer. Polysaccharides isolated from plants have been regarded as an …

The mitogen-activated protein kinase (MAPK) family is an important bridge in the
transduction of extracellular and intracellular signals in different responses at the cellular …

Abstract Background Circular RNAs (circRNAs) play important roles in tumourigenesis and
tumour progression. However, the expression profiles and functions of circRNAs in …

The formation of new blood vessels is essential for normal development, tissue repair and
tumor growth. Here we show that inhibition of the kinase p38α enhances angiogenesis in …

Toll-like receptors (TLRs) are important sensors of foreign microbial components as well as
products of damaged or inflamed self tissues. Upon sensing these molecules, TLRs initiate a …

P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states
such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and …

Both chronic obstructive pulmonary disease (COPD) and lung cancer are major causes of
death worldwide. In most cases this reflects cigarette smoke exposure which is able to …