Strategies to promote bone regeneration have been always the focus of investigations since
the skeleton plays important roles like mechanical support, organ protection, and mineral …

Distraction osteogenesis (DO) is a kind of bone regeneration technology. The principle is to
incise the cortical bone and apply continuous and stable distraction force to the fractured …

Bone defects are difficult to heal, which conveys a heavy burden to patients' lives and their
economy. The total flavonoids of Rhizoma drynariae (TFRD) can promote the osteogenesis …

Background: In the clinical treatment of large bone defects, distraction osteogenesis can be
used. However, some patients may suffer from poor bone regeneration, or even delayed …

Distraction osteogenesis (DO) is a physiological process that generates new bone tissue
formation, using progressively separated bone fragments. Recently, several techniques …

This review is an attempt to investigate the effects of local delivery of melatonin along with
bone grafts to improve osteogenesis. A systematic literature search was done from January …

Pulsed electromagnetic field (PEMF) therapy and melatonin (MEL) supplementation are
expected to be important strategies for the treatment of osteoporosis. The aim of the current …

Melatonin improves fracture healing, but the long-term use of melatonin seems
impracticable in the treatment of fracture due to side effects caused by hormonal stress on …

The prevalence of senile osteoporosis increases progressively with aging of the world
population and the osteoporotic fractures among old people has become a major public …

Background and Objectives: This study aimed to histologically evaluate the effects of local
melatonin application at different doses on bone fracture healing. Materials and Methods …