Runs of homozygosity: windows into population history and trait architecture

FC Ceballos, PK Joshi, DW Clark, M Ramsay… - Nature Reviews …, 2018 - nature.com
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each
parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding …

Tracing the peopling of the world through genomics

R Nielsen, JM Akey, M Jakobsson, JK Pritchard… - Nature, 2017 - nature.com
Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …

The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes

S Mallick, A Micco, M Mah, H Ringbauer, I Lazaridis… - Scientific Data, 2024 - nature.com
More than two hundred papers have reported genome-wide data from ancient humans.
While the raw data for the vast majority are fully publicly available testifying to the …

Palaeogenomics of upper palaeolithic to neolithic European hunter-gatherers

C Posth, H Yu, A Ghalichi, H Rougier, I Crevecoeur… - Nature, 2023 - nature.com
Modern humans have populated Europe for more than 45,000 years,. Our knowledge of the
genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to …

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

W Barrie, Y Yang, EK Irving-Pease, KE Attfield… - Nature, 2024 - nature.com
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …

Grey wolf genomic history reveals a dual ancestry of dogs

A Bergström, DWG Stanton, UH Taron, L Frantz… - Nature, 2022 - nature.com
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and
they remained widespread throughout the last Ice Age when many other large mammal …

The genetic history of the Southern Arc: A bridge between West Asia and Europe

I Lazaridis, S Alpaslan-Roodenberg, A Acar, A Açıkkol… - Science, 2022 - science.org
By sequencing 727 ancient individuals from the Southern Arc (Anatolia and its neighbors in
Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic …

Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry

M Hajdinjak, F Mafessoni, L Skov, B Vernot, A Hübner… - Nature, 2021 - nature.com
Modern humans appeared in Europe by at least 45,000 years ago,,,–, but the extent of their
interactions with Neanderthals, who disappeared by about 40,000 years ago, and their …

Language trees with sampled ancestors support a hybrid model for the origin of Indo-European languages

P Heggarty, C Anderson, M Scarborough, B King… - Science, 2023 - science.org
The origins of the Indo-European language family are hotly disputed. Bayesian phylogenetic
analyses of core vocabulary have produced conflicting results, with some supporting a …

The genomic history of the Iberian Peninsula over the past 8000 years

I Olalde, S Mallick, N Patterson, N Rohland… - Science, 2019 - science.org
We assembled genome-wide data from 271 ancient Iberians, of whom 176 are from the
largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect …