Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal common malignancy, with little
improvement in patient outcomes over the past decades. Recently, subtypes of pancreatic …

LIN28B is a homologue of LIN28 that induces pluripotency when expressed in conjunction
with OCT4, SOX2, and KLF4 in somatic fibroblasts. LIN28B represses biogenesis of let-7 …

Environmental stimuli often lead to heterogeneous cellular responses and transcriptional
output. We developed single-cell RNA and Immunodetection (RAID) to allow combined …

The concept that the mammalian glycoprotein vitronectin acts as a biological 'glue'and key
controller of mammalian tissue repair and remodelling activity is emerging from nearly 50 …

Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …

Human kallikrein 5 (KLK5) is a member of the human kallikrein gene family of serine
proteases. Preliminary results indicate that the protein, hK5, may be a potential serological …

Recently, we described phorbol ester–induced expression of the brain and skin serine
proteinase Bssp/kallikrein 6 (Klk6), the mouse orthologue of human KLK6, in mouse back …

Semen liquefaction is a proteolytic process where a gel-like ejaculated semen becomes
watery due to the enzymatic activity of prostate-derived serine proteases in the female …