Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …

Spatial omics has been widely heralded as the new frontier in life sciences. This term
encompasses a wide range of techniques that promise to transform many areas of biology …

The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

Highly multiplexed spatial map** of transcripts within tissues allows for investigation of the
transcriptomic and cellular diversity of mammalian organs previously unseen. Here we …

Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of
publications presenting novel methods for obtaining spatially resolved information for any …

The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

We present b arcoded o ligonucleotides l igated on R NA a mplified for m ultiplexed and
parallel ins itu analyses (BOLORAMIS), a reverse transcription-free method for spatially …

Abstract The Xenium In Situ platform is a new spatial transcriptomics product
commercialized by 10X Genomics capable of map** hundreds of transcripts in situ at a …