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The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection
The incidence of early-onset colorectal cnacer—ie, colorectal cancer diagnosed in patients
under the age of 50 years—has been increasing around the world. This Series paper …
under the age of 50 years—has been increasing around the world. This Series paper …
Genetic predisposition to colorectal cancer: how many and which genes to test?
Colorectal cancer is one of the most common tumors, and genetic predisposition is one of
the key risk factors in the development of this malignancy. Lynch syndrome and familial …
the key risk factors in the development of this malignancy. Lynch syndrome and familial …
[HTML][HTML] Lynch syndrome genetics and clinical implications
Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
[HTML][HTML] Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines
Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …
according to guidelines that are not age-specific. A multidisciplinary international group …
Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls
We present the case of a patient with Lynch syndrome and metastatic colorectal carcinoma
(mCRC). The initial immunohistochemistry (IHC) test for deficient mismatch repair gave a …
(mCRC). The initial immunohistochemistry (IHC) test for deficient mismatch repair gave a …
Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance
The Asia-Pacific region has the largest number of cases of colorectal cancer (CRC) and one
of the highest levels of mortality due to this condition in the world. Since the publishing of two …
of the highest levels of mortality due to this condition in the world. Since the publishing of two …
Universal germline genetic testing for hereditary cancer syndromes in patients with solid tumor cancer
ED Esplin, SM Nielsen, SL Bristow, JE Garber… - JCO Precision …, 2022 - ascopubs.org
Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …
[HTML][HTML] Birth cohort colorectal cancer (CRC): implications for research and practice
Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …
Multigene panel testing yields high rates of clinically actionable variants among patients with colorectal cancer
SE Coughlin, B Heald, DF Clark, SM Nielsen… - JCO Precision …, 2022 - ascopubs.org
PURPOSE Whether germline multigene panel testing (MGPT) should be performed in all
individuals with colorectal cancer (CRC) remains uncertain. Therefore, we aimed to …
individuals with colorectal cancer (CRC) remains uncertain. Therefore, we aimed to …
Hereditary colorectal cancer
Around 10% to 16% 1–4 of all individuals with colorectal cancer have a pathogenic variant
in a cancer susceptibility gene (Table 1). While not all of these genes have been associated …
in a cancer susceptibility gene (Table 1). While not all of these genes have been associated …