Targeted drugs disrupting proteins that are dysregulated in cancer have emerged as
promising treatments because of their specificity to cancer cell aberrations and thus their …

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition arising due to
complex interactions between multiple genetic and environmental factors. Despite recent …

The advent of next-generation sequencing has introduced new opportunities in analyzing
gene expression data. Research in systems biology has taken advantage of these …

Cardiovascular disease (CVD) is a collective term for disorders of the heart and blood
vessels. The molecular events and biochemical pathways associated with CVD are difficult …

We describe a precision medicine workflow, the integrated single nucleotide polymorphism
network platform (iSNP), designed to determine the mechanisms by which SNPs affect …

The epithelial lining of the small intestine consists of multiple cell types, including Paneth
cells and goblet cells, that work in cohort to maintain gut health. 3D in vitro cultures of human …

Type 1 diabetes (T1D) occurs as a consequence of an autoimmune attack against
pancreatic β-cells. Due to a lack of a clear understanding of the T1D pathogenesis, the …

Affinity fingerprints report the activity of small molecules across a set of assays, and thus
permit to gather information about the bioactivities of structurally dissimilar compounds …

Significant successes in machine learning approaches to image analysis for various
applications have energized strong interest in automated diagnostic support systems for …

Protein-protein interaction network (PPIN) analysis is a widely used method to study the
contextual role of proteins of interest, to predict novel disease genes, disease or functional …