Gut microbiome and metabolites in systemic lupus erythematosus: link, mechanisms and intervention

L Zhang, P Qing, H Yang, Y Wu, Y Liu… - Frontiers in …, 2021‏ - frontiersin.org
Systemic lupus erythematosus (SLE), often considered the prototype of autoimmune
diseases, is characterized by over-activation of the autoimmune system with abnormal …

Genome of the Extremely Radiation-Resistant Bacterium Deinococcus radiodurans Viewed from the Perspective of Comparative Genomics

KS Makarova, L Aravind, YI Wolf… - Microbiology and …, 2001‏ - Am Soc Microbiol
The bacterium Deinococcus radiodurans shows remarkable resistance to a range of
damage caused by ionizing radiation, desiccation, UV radiation, oxidizing agents, and …

Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

TM Greiling, C Dehner, X Chen, K Hughes… - Science Translational …, 2018‏ - science.org
The earliest autoantibodies in lupus are directed against the RNA binding autoantigen
Ro60, but the triggers against this evolutionarily conserved antigen remain elusive. We …

Origins of highly mosaic mycobacteriophage genomes

ML Pedulla, ME Ford, JM Houtz, T Karthikeyan… - Cell, 2003‏ - cell.com
Bacteriophages are the most abundant organisms in the biosphere and play major roles in
the ecological balance of microbial life. The genomic sequences of ten newly isolated …

An expanding universe of noncoding RNAs

G Storz - Science, 2002‏ - science.org
Noncoding RNAs (ncRNAs) have been found to have roles in a great variety of processes,
including transcriptional regulation, chromosome replication, RNA processing and …

[HTML][HTML] Functional roles of non-coding Y RNAs

MP Kowalski, T Krude - The international journal of biochemistry & cell …, 2015‏ - Elsevier
Non-coding RNAs are involved in a multitude of cellular processes but the biochemical
function of many small non-coding RNAs remains unclear. The family of small non-coding Y …

Comparative genomics and evolution of proteins involved in RNA metabolism

V Anantharaman, EV Koonin… - Nucleic acids research, 2002‏ - academic.oup.com
RNA metabolism, broadly defined as the compendium of all processes that involve RNA,
including transcription, processing and modification of transcripts, translation, RNA …

RNA chaperones, RNA annealers and RNA helicases

L Rajkowitsch, D Chen, S Stampfl, K Semrad… - RNA biology, 2007‏ - Taylor & Francis
RNA molecules face difficulties when folding into their native structures. In the cell, proteins
can assist RNAs in reaching their functionally active states by binding and stabilizing a …

An abundance of RNA regulators

G Storz, S Altuvia, KM Wassarman - Annu. Rev. Biochem., 2005‏ - annualreviews.org
▪ Abstract The importance of small, noncoding RNAs that act as regulators of transcription, of
RNA modification or stability, and of mRNA translation is becoming increasingly apparent …

RNA under attack: cellular handling of RNA damage

EJ Wurtmann, SL Wolin - Critical reviews in biochemistry and …, 2009‏ - Taylor & Francis
Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can
include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein …