Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …