This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …

Hallucinations, perceptions in the absence of objectively identifiable stimuli, illustrate the
constructive nature of perception. Here, we highlight the role of prior beliefs as a critical …

Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis:
dopamine, serotonin, and glutamate Page 1 Beyond the dopamine hypothesis of schizophrenia …

Importance Ketamine hydrochloride is increasingly used to treat depression and other
psychiatric disorders but can induce schizophrenia-like or psychotomimetic symptoms …

Ketamine is a noncompetitive antagonist of N-methyl-d-asparate (NMDA) receptor and has
been long used as an anesthetic agent in humans and veterinary medicine. The present …

Twenty years have passed since the dysconnection hypothesis was first proposed (Friston
and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous …

Functional neuroimaging research on depression has traditionally targeted neural networks
associated with the psychological aspects of depression. In this study, instead, we focus on …

Interoception—the perception of internal bodily signals—has emerged as an area of interest
due to its implications in emotion and the prevalence of dysfunctional interoceptive …

The problem of whether and how information is integrated across hierarchical brain
networks embodies a fundamental tension in contemporary cognitive neuroscience, and by …

The predominant inhibitory neurotransmitter in the brain, γ-aminobutyric acid (GABA), acts at
ionotropic GABAA receptors to counterbalance excitation and regulate neuronal firing …