Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

Despite the discovery of the tuberculosis (TB) bacillus over 100 years ago and the
availability of effective drugs for over 50 years, there remain a number of formidable …

The factors that govern the development of tuberculosis disease are incompletely
understood. We hypothesized that some strains of Mycobacterium tuberculosis (M …

Several genes coding for different cytokines may affect host susceptibility to tuberculosis.
This study investigates the relationship of the single base change polymorphic variants …

Infection with Mycobacterium tuberculosis results in disease in 5–10% of exposed
individuals, whereas the remainder controls infection effectively. Similar inter-individual …

Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-
control, candidate-gene, family studies and genome-wide association studies (GWAS) …

The importance of host genetic factors in determining susceptibility to tuberculosis (TB) has
been studied extensively using various methods, such as case‐control, candidate gene and …

The historical impression that tuberculosis was an inherited disorder has come full circle and
substantial evidence now exists of the human genetic contribution to susceptibility to …

In humans, genetic factors have long been suspected to contribute to the onset and outcome
of tuberculosis. Such effects are difficult to identify owing to their complex inheritance, and to …

Twenty-seven polymorphisms from 12 genes have been investigated for association with
tuberculosis (TB) in up to 514 cases and 913 controls from Karonga district, northern Malawi …