Constitutive models are important to biomechanics for two key reasons. First, constitutive
modelling is an essential component of characterizing tissues' mechanical properties for …

In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …

Thrombus fragmentation during endovascular stroke treatment, such as mechanical
thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical …

The biomechanical properties of blood clots, which are dictated by their compositions and
micro-structures, play a critical role in determining their fates, ie, occlusion, persistency, or …

Acute ischemic stroke occurs when a thrombus obstructs a cerebral artery, leading to sub-
optimal blood perfusion to brain tissue. A recently developed, preventive treatment is the …

Stent retriever thrombectomy is a pre-eminent treatment modality for large vessel ischaemic
stroke. Simulation of thrombectomy could help understand stent and clot mechanics in failed …

Thromboembolism–that is, clot formation and the subsequent fragmentation of clot–is a
leading cause of death worldwide. Clots' mechanical properties are critical determinants of …

Mechanical thrombectomy (MT) treatment of acute ischemic stroke (AIS) patients typically
involves use of stent retrievers or aspiration catheters alone or in combination. For in silico …

Soft materials are an important class of materials. They play critical roles both in nature, in
the form of soft tissues, and in industrial applications. Quantifying their mechanical …

Mechanical thrombectomy to treat large vessel occlusions (LVO) causing a stroke is one of
the most effective treatments in medicine, with a number needed to treat to improve clinical …