Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
DNA repair inhibitors: potential targets and partners for targeted radionuclide therapy
The present review aims to explore the potential targets/partners for future targeted
radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively …
radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively …
STING enhances cell death through regulation of reactive oxygen species and DNA damage
Resistance to DNA-damaging agents is a significant cause of treatment failure and poor
outcomes in oncology. To identify unrecognized regulators of cell survival we performed a …
outcomes in oncology. To identify unrecognized regulators of cell survival we performed a …
Concurrent olaparib and radiotherapy in patients with triple-negative breast cancer: the phase 1 olaparib and radiation therapy for triple-negative breast cancer trial
P Loap, D Loirat, F Berger, M Rodrigues… - Jama …, 2022 - jamanetwork.com
Importance Triple-negative breast cancer (TNBC) cells are sensitive to poly (adenosine
diphosphate ribose) polymerase (PARP) inhibitors used as radiosensitizers. Whether …
diphosphate ribose) polymerase (PARP) inhibitors used as radiosensitizers. Whether …
Short-term CDK4/6 inhibition radiosensitizes estrogen receptor–positive breast cancers
Abstract Purpose: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have improved
progression-free survival for metastatic, estrogen receptor–positive (ER+) breast cancers …
progression-free survival for metastatic, estrogen receptor–positive (ER+) breast cancers …
Tailoring treatment for patients with inflammatory breast cancer
AB Newman, F Lynce - Current Treatment Options in Oncology, 2023 - Springer
Opinion statement Inflammatory breast cancer (IBC) is a rare but aggressive subtype of
breast cancer that has a propensity for locoregional recurrence and distant metastasis and is …
breast cancer that has a propensity for locoregional recurrence and distant metastasis and is …
Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer
Breast cancer is the most prevalent non-skin cancer diagnosed in females and develo**
novel therapeutic strategies to improve patient outcomes is crucial. The immune system …
novel therapeutic strategies to improve patient outcomes is crucial. The immune system …
Functional regulations between genetic alteration-driven genes and drug target genes acting as prognostic biomarkers in breast cancer
L Wang, L Yu, J Shi, F Li, C Zhang, H Xu, X Yin… - Scientific reports, 2022 - nature.com
Differences in genetic molecular features including mutation, copy number alterations and
DNA methylation, can explain interindividual variability in response to anti-cancer drugs in …
DNA methylation, can explain interindividual variability in response to anti-cancer drugs in …
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition
G Raspaglio, M Buttarelli, F Filippetti, A Battaglia… - Cell Death & …, 2021 - nature.com
Cervical cancer (CC) is the fourth most common cause of cancer-related death in women.
According to international guidelines, a standard treatment for locally advanced cervical …
According to international guidelines, a standard treatment for locally advanced cervical …
NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non‐inflammatory breast cancers
Inflammatory breast cancer (IBC) is the most pro‐metastatic form of breast cancer. Better
understanding of its pathophysiology and identification of actionable genetic alterations …
understanding of its pathophysiology and identification of actionable genetic alterations …