Several combinatorial methods have been developed to create focused or diverse chemical
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …

A historical overview of peptide chemistry from T. Curtius to E. Fischer to M. Bergmann and
L. Zervas is first presented. Next, the fundamentals of peptide synthesis with a focus on solid …

Urease is a virulence factor found in various pathogenic bacteria. It is essential in
colonization of a host organism and in maintenance of bacterial cells in tissues. Due to its …

BACKGROUND: The peptide microarray is a novel assay that facilitates high-throughput
screening of peptides with a small quantity of sample. OBJECTIVE: We sought to use …

The size of information that can be stored in nucleic acids, proteins, and carbohydrates was
calculated. The number of hexamers for peptides is 64,000,000 (20 6) and seems to be …

Combinatorial preparation and HTS of arrays of compounds have increased the speed of
drug discovery. A strong impulse in this field has come by the introduction of the solid phase …

Peptide microarrays have become increasingly accessible in recent years and as a result,
more widely applied. Beyond its initial utility in substrate profiling, researchers are adopting …

While a well-established process for lead compound discovery in for-profit companies, high-
throughput screening is becoming more popular in basic and applied research settings in …

Alzheimer's disease (AD) is an age-related disease caused by abnormal accumulation of
amyloid-β in the brain leading to progressive tissue degeneration. Flurbiprofen (FP), a drug …

Protein, peptide and small molecule microarrays are valuable tools in biological research. In
the last decade, substantial progress has been achieved to make these powerful …