Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

Precision medicine requires an understanding of cancer genes and mutational processes,
as well as an appreciation of the extent to which these are found heterogeneously in cancer …

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …

Numerous large-scale genomic studies of matched tumor-normal samples have established
the somatic landscapes of most cancer types. However, the downstream analysis of data …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Background Base substitution catalogues represent historical records of mutational
processes that have been active in a cell. Such processes can be distinguished by various …

Many traditional pharmacopeias include Aristolochia and related plants, which contain
nephrotoxins and mutagens in the form of aristolochic acids and similar compounds …

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Intrahepatic cholangiocarcinoma (ICC) is a fatal primary liver cancer (PLC) that affects 5–
10% of all PLCs. Here we sequence tumour and matching control sample pairs of a large …

Genomic alterations driving tumorigenesis result from the interaction of environmental
exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is …